Iimveliso
3,3'- diindolylmethane
Inkcazo
I-3,3'-diindolylmethane yindawo yokuxuba amayeza;Inokufumaneka kwi-phytochemicals yendalo ye-Cruciferae Plants, i-acid catalyzed reaction products, i-indole-3-methanol;Inomsebenzi we-anti-tumor agent;Phantsi kwemeko yoxinaniso oluphezulu ngokwentelekiso, i-derivative ayinakukhawulezisa ngokuthe ngqo i-apoptosis yeeseli zomhlaza womntu, kodwa iphinde ikhuthaze umkhondo ukuphembelela i-apoptosis yeeseli zomhlaza womntu;I-Chemicalbookdim yenza i-G1 i-ring inhibition ye-cell ring inhibition kwi-cancer yebele yomntu i-MCF-7 iiseli ngokusebenzisa indlela kunye nokubonakalisa ukubandakanywa;I-Dim yi-inhibitor enamandla ye-mitochondrial h + -atpase;Njengomkhuthazi omtsha wokukhula kwezityalo, i-dim kunye ne-derivatives yayo isetyenziswe kuphando lwenkqubo eco-friendly.
Ulwazi lweMveliso
Inombolo yeCas: 1968-05-4
Ucoceko:≥98%
Ifomula yomgaqo: C17H14N2
Ifomula Wt.ixabiso: 246.31
Igama leMchiza:3,3'-Diindolylmethane
Isithethantonye : :3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Isityalo:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE
Indawo yokunyibilika:167°C
Indawo yokuBilisa:230 °C
Ukunyibilika: I-Chloroform (Kancinci), iMethanol (Kancinci)
Imbonakalo: Umgubo omhlophe ongekho
Ukuthumela ngenqanawa kunye noGcino
Uzinzo lokugcina olucetyiswayo lobushushu bokugcina -20°C.
Ukulungiselela Indawo ye-indole (1.17 g, 10 mmol), CTAB (50% mol) kunye ne-oxalic acid (50% mol) kwi-25 ml ye-flask enentamo enye ejikelezayo ephantsi, yongeza i-5 ml yamanzi adibeneyo, ugxobhoze ngokucokisekileyo imizuzu emi-5 kwaye emva koko. yongeza isisombululo se-aqueous formaldehyde (isisombululo se-0.38 g, i-5 mmol formaldehyde) i-dropwise.Yenza i-3 h kwiqondo lokushisa kwaye uyeke ukuphendula.Isisombululo sokusabela sikhutshwe kunye ne-15 ml ye-ethyl acetate kwiindawo ezintathu, kwaye isigaba se-organic saqokelelwa kwaye somiswa nge-anhydrous Na2SO4 kwiiyure ze-5.I-solvent yasuswa phantsi koxinzelelo oluncitshisiweyo kwaye iphinda ihlaziywe kumxube we-methanol kunye namanzi (i-methanol / H2ChemicalbookO = 10/1) ukunika i-white solid 3,3'-diindolylmethane kwi-85% yesivuno.I-Bioactivity3,3'-Diindolylmethane (DIM) iyona mveliso yokugaya i-indole-3-carbinol, into enokuthi ibe yinto echasene nomhlaza kwimifuno ye-cruciferous.3,3'-Diindolylmethane (DIM) ngumchasi ococekileyo onamandla we-androgenreceptor (AR) .
Uphononongo lwe-in vitro lubonise ukuba i-DIM iyi-radioprotector esebenzayo kunye ne-mitigator, esebenza ngokuvuselela iimpendulo ze-DDR-eziqhutywa yi-ATM kunye ne-NF-κB yokubonisa ukusinda.DIM inokuthintela ukuhlasela kwe-tumor cell, i-angiogenesis, ukwanda kunye nokwenza i-apoptosis ngokumodareyitha iindlela zokubonisa. njenge-AKT, NF-κB kunye ne-FOXO3.Iyakwazi nokuthintela i-estrogen-induced gene expression kwaye ibangele uxinzelelo lwe-endoplasmic reticulum.I-chemicalbookDIM inokuguqula i-estrogen metabolism kwaye ichase i-estrogen kunye nomsebenzi we-androgen receptor.Uphononongo lwe-vivo lubonise ukuba i-DIM iyasebenza ngokuchasene nemitha yenkqubo emva kolawulo oluninzi.Kuvavanyo lwe-vivo, i-DIM ibonelele ngokhuseleko lwemitha okanye ukuthomalalisa.Kwizicubu eziqhelekileyo, i-DIM yenza i-ATM isebenze.I-diM inokulawulwa kwiimpuku ngokuzaliswa komlomo (250 mg/kg) ngokufumaneka okuphezulu kwe-bioavailability kwaye akukho t.
