I-Polyinosinic Acid-polycytidylic Acid

Isicelo
I-Poly I: I-C iyaziwa ngokusebenzisana ne-toll-like receptor 3 (TLR3), ebonakaliswa kwi-endosomal membrane ye-B-cell, i-macrophages kunye neeseli ze-dendritic.I-Poly I:C ngokwesakhiwo iyafana ne-RNA ephindwe kabini, ekhoyo kwezinye iintsholongwane kwaye "yindalo" evuselela i-TLR3.Ke, iPoly I:C inokuthathwa njenge-analog yokwenziwa ye-RNA enemisonto ephindwe kabini kwaye sisixhobo esiqhelekileyo sophando lwezenzululwazi kukhuselo lomzimba.

Uphawu
Le mveliso i-synthetic interferon inducer, eyi-polyribonucleotide ephindwe kabini ehlanganiswe ne-polyinosinic acid kunye ne-polycytidylic acid.Ekubeni i-interferon iluhlobo oluthile lwezilwanyana, kunzima ukulungiselela ubuninzi obuninzi besicelo seklinikhi, ngoko ke isetyenziswa kakhulu njenge-interferon inducer ukukhupha i-interferon.Ukongeza, i-polyinosinic acid isenayo indima ye-immune adjuvant, enokuthi ivuselele inkqubo ye-reticuloendothelial, iphucule umsebenzi we-phagocytic we-phagocytes, iphucule ukubunjwa kwamajoni omzimba, ivuselele ukusabela kwe-allograft kunye nokulibaziseka kokusabela komzimba.Ine-anti-spectrum ebanzi ye-antiviral kunye ne-antitumor effects.

Ukusetyenziswa kunye neendlela zokudibanisa
Isishwankathelo
I-Polycytidylic acid, eyaziwa ngokuba yi-polyinosinic acid, i-polyhypoxanthine nucleotide kunye ne-polycytidine nucleotide, yenye ye-polynucleotides, equlathe ikhonkco eliphindwe kabini le-polynucleotide ye-polyinosinic acid kunye ne-polycytidylic acid, eneempawu zokuqhawula umbala kunye nendawo yokunyibilika, kunye ne-20 ℃. .

Iziphumo ze-Pharmacological
1. I-Polyinosinic acid inesiphumo esihle sokukhuthaza kuzo zombini i-immunity ecacileyo kunye neyiyo ethile yomzimba.
(1) I-Polymyocytes iphakamisa umsebenzi weeseli zomzimba
(2) Iipolymyocyte zikhuthaza ukukhuselwa kwee-cytokines ezahlukeneyo
(3) Ukungeniswa kweprotheni ye-Mx nge-polymyocytes
(4) Iipolymyocyte zikhuthaza ukuveliswa kwee-antibodies kwi-vivo

2. Impembelelo ye-anti-viral ye-polymyocytes
Iimvavanyo ze-in vitro, iimvavanyo zezilwanyana kunye nezilingo zeklinikhi zabantu ziye zabonisa ukuba iipolymyxins zineempembelelo ezininzi ze-antiviral, ezibandakanya i-yellow fever virus, i-encephalomyelitis virus, i-Rift Valley fever virus, i-avian influenza virus, intsholongwane ye-hepatitis, intsholongwane ye-AIDS, unyawo kunye nomlomo. intsholongwane yesifo, i-conjunctivitis virus, i-virus ye-rash elula, i-virus ye-Mengo, i-virus ye-pox, i-virus ye-myocarditis, i-virus ye-Aleutian, i-coxsackievirus, njl. Kuye kwafakazelwa ukuba umphumo wokuthintela we-Polymyxa ungcono kunempembelelo yonyango yosulelo lwentsholongwane.

Isicelo
I-1.I-homopolymer ephindwe kabini enokuthi isetyenziswe njengomzekelo we-RNA ukufunda ukubonakaliswa kweeseli kwinqanaba le-TLR3 eqaphela i-RNA ephindwe kabini, eyona nto ibangela ukuba i-immune iphendule kwiintsholongwane zentsholongwane.

2.Idityaniswe ne-polyinosinic acid ukwenza iseli ye-polyinosinic, esetyenziselwa unyango lwe-hepatitis yentsholongwane, i-herpes zoster, i-herpes simplex keratitis, i-herpes stomatitis, i-epidemic hemorrhagic fever, njl.

3. Ine-immune adjuvant effect, ivuselela inkqubo ye-reticuloendothelial, iphucula i-phagocytosis, iphucula ukubunjwa kwe-antibody, ivuselela i-allograft reaction kunye nokulibaziseka ukusabela komzimba.Inomphumela obanzi we-antiviral kunye ne-antitumor effect.Isetyenziswa ikakhulu ekliniki: ukuthintela okanye unyango lwezifo zentsholongwane, unyango lwe-herpes zoster, i-herpetic keratitis, i-hepatitis yentsholongwane.Ukunyangwa kwe-Adjuvant yamathumba.Iziphumo ezibi ikakhulu ziquka i-hypothermia yexeshana kunye neemeko zomkhuhlane ophezulu ongaphezu kwe-38℃, othi uthobe ngokwawo kwiintsuku ezi-1-2.Ukuba umkhuhlane awupheli kwiintsuku ezi-2, ichiza kufuneka lipheliswe ngokukhawuleza.Ubuthathaka, umlomo owomileyo, isiyezi, isicaphucaphu, njl.