Kutshanje, abaphandi abavela kwiYunivesithi yaseGeorgia kunye neYunivesithi yaseTufts baye bafumanisa ukuba i-folic acid inokukhuthaza ukwanda kwe-stem cell ngokusebenzisa inkcubeko ye-in vitro kunye neenkqubo zemodeli yezilwanyana, ezingaxhomeki kwindima yayo njengevithamini, kwaye uphando olufanelekileyo lwapapashwa kwijenali yamazwe ngamazwe. Iseli yoPhuhliso.
I-Folic acid, nokuba yi-vitamin B eyongezelelweyo okanye i-folic acid yendalo efunyenwe ekutyeni, iyimfuneko ekusebenzeni okuqhelekileyo kwazo zonke iiseli emzimbeni kwaye ibalulekile ekuthinteleni iziphene zokukhula kwiintsana ezisanda kuzalwa.Kweli nqaku, abaphandi bafumanisa kuqala ukuba i-stem cell yabantu abadala inokulawulwa yinto ephuma ngaphandle komzimba wesilwanyana, oko kukuthi, i-folic acid evela kwiibhaktheriya, njengeemodeli ze-nematodes ezifana ne-Caenorhabditis elegans.
Umphandi u-Edward Kipreos uthe uphando lwethu lubonisa ukuba iiseli ze-germ stem kwi-caenorhabditis elegans zinokwahlulwa ngokukhuthazwa kwe-folate kwi-bacterial diet;i-folic acid iyimfuneko ye-vitamin ye-B, kodwa abaphandi bafumanisa ukuba ukukwazi kwe-folic acid ekhethekileyo ukuvuselela iiseli zentsholongwane kunokungaxhomeki kwindima yayo njenge-vitamin B, enokuthi ibonise ukuba i-folic acid idlala indima ngokuthe ngqo njenge-molecule yomqondiso.
I-folic acid eyenzeke ngokwendalo ithande ukuza kwiintlobo ezininzi zeekhemikhali, ezinje nge-folic acid ekutyeni okanye kwi-metabolism esebenzayo ye-folic acid emzimbeni womntu, kwaye i-folic acid ikwakhona kwifomu enkulu yokwenziwa ekutyeni okuqinisiweyo kunye nezongezo zevithamini.I-Folic acid yafunyanwa ngo-1945, ukususela kumhla wokufunyanwa kwayo, abaphandi abaninzi baye bafunda kakhulu, kwaye ngoku kukho amaphepha ophando angaphezu kwama-50,000 anxulumene ne-folic acid, kodwa olu pho nonongo lukhethekileyo, kuba uphando lubonisa indima entsha. ye-folic acid, kunokuba indima ye-folic acid evezwe kwizifundo zangaphambili.
I-Folic acid okwangoku yongezwa kwiisiriyeli e-United States nakwamanye amazwe, kwaye ukongezwa kwe-folic acid kunokunceda kakhulu ekunciphiseni ukuzalwa kweentsana ezineziphene zophuhliso lwe-neural tube, kodwa indima ye-folic acid yokungathembeli kwiivithamini inokunceda ekuboneleleni ngendlela yesibini. umzimba womntu.Kwinqaku, abaphandi bafumanisa ukuba i-folate receptor ekhethekileyo ebizwa ngokuba yi-FOLR-1 iyimfuneko ukukhuthaza ukukhula kweeseli ze-stem zokuzala kumzimba we-Caenorhabditis elegans.
Kwangaxeshanye, abaphandi baye baqaphela inkqubo ye-FOLR-1 receptors ekhuthaza i-germ cell tumors kwi-caenorhabditis elegans, enokuthi ifane nenkqubo ye-folic acid receptors evuselela ukuqhubela phambili kwee-cancer ezikhethekileyo kwizinto eziphilayo zabantu;kunjalo, i-receptors isenokungabi yimfuneko yokuthutha i-folic acid kwiiseli zokusetyenziswa kwevithamini, kodwa inokuvuselela ukuhlukana kweeseli.Okokugqibela, abaphandi bathi uphononongo lunokusinika isixhobo esitsha sokunceda ukufunda izinto eziphambili zemfuza.
Ixesha lokuposa: Mar-30-2022