Adenosine

Isicelo
I-Adenosine isetyenziselwa ukunceda ukubuyisela ukubetha kwentliziyo okuqhelekileyo kubantu abaneengxaki ezithile zesigqi sentliziyo.
I-Adenosine ikwasetyenziswa ngexesha lovavanyo loxinzelelo lwentliziyo.
I-Adenosine ingasetyenziselwa iinjongo ezingadweliswanga kwesi sikhokelo samayeza.

I-Adenosine, i-compound equkethe i-N-9 ye-adenine edityaniswe ne-C-1 ye-D-ribose nge-b-glycosidic bond, ine-chemical formula C10H13N5O4 kunye ne-phosphate ester yayo i-adenosine acid.I-Adenosine yi-nucleoside engapheliyo esasazeka kwiiseli zomntu kwaye ingangena ngokuthe ngqo kwi-myocardium ukuvelisa i-adenosine acid nge-phosphorylation, ebandakanyeka kwi-metabolism yamandla e-myocardial, kunye nokunciphisa imithwalo ye-coronary kunye nokwandisa ukuhamba kwegazi.Isetyenziselwa unyango lwe-supraventricular tachycardia.I-Adenosine ineempembelelo zomzimba kwi-cardiovascular system kunye nezinye iinkqubo ezininzi kunye nezicubu zesihlunu.I-Adenosine yinto ebalulekileyo ephakathi esetyenziswa kwi-synthesis ye-adenosine triphosphate (ATP), i-adenine, i-adenosine acid, kunye ne-adenosine asiaticum.
Kwakhona i-antiarrhythmic agent eguqula i-paroxysmal supraventricular tachycardia kwisigqi se-sinus.Isetyenziselwa i-supraventricular arrhythmias ehambelana ne-atrioventricular.Unyango lwe-angina pectoris, infarction ye-myocardial, insufficiency ye-coronary, i-atherosclerosis, uxinzelelo lwegazi oluyimfuneko, ukuphazamiseka kwe-cerebrovascular, i-post-stroke sequelae, i-progressive muscle atrophy, njl. Kwakhona isetyenziswe kwizifundo ze-biochemical.
I-Adenosine i-endogenous purine nucleoside eyenza i-AV node conduction icothe, ivimba i-AV nodal fold pathway, kwaye ibuyisela isigqi esiqhelekileyo se-sinus kwizigulane ezine-paroxysmal supraventricular tachycardia (PSVT) (kunye okanye ngaphandle kwe-preexcitation syndrome).I-Adenosine ithathwa ngokukhawuleza ngamaseli abomvu egazi kwaye ngoko inexesha elifutshane lesenzo, kunye ne-plasma-half-life engaphantsi kwe-10 s.Olona hlobo luqhelekileyo lwe-PSVT luhamba kwindlela yokubuyela emva, ngoko ke i-adenosine iyasebenza ekupheliseni olu hlobo lwe-arrhythmia.Kwi-non-atrial okanye i-sinus node regressive arrhythmias (umzekelo, i-atrial flutter, i-fibrillation ye-atrial, i-tachycardia ye-atrial, i-tachycardia ye-ventricular), i-adenosine ayipheli, kodwa inokuvelisa i-atrioventricular okanye i-ventricular block yesikhashana, enokunceda ukwenza ukuxilongwa okwahlukileyo.