5-Fluorocytosine

Isicelo
I-Flucytosine ngomlomo isetyenziselwa ukunyanga izifo ezinzulu ezibangelwa yi-Candida okanye i-Cryptococcus neoformans.Ingasetyenziselwa unyango lwe-chromomycosis (chromoblastomycosis), ukuba iintlobo ezithintekayo zibangela usulelo.I-Flucytosine mayingasetyenziswa njenge-arhente eyodwa kusulelo lomngundo olusongela ubomi ngenxa yeziphumo ezibuthathaka ze-antifungal kunye nophuhliso olukhawulezayo lokuxhathisa, kodwa kunoko kudityaniswe ne-amphotericin B kunye/okanye i-azole antifungals efana ne-fluconazole okanye i-itraconazole.Izifo ezincinci ezifana ne-candidal cystitis zinokunyangwa nge-flucytosine yodwa.Kwamanye amazwe, unyango olucothayo lokufakwa kwi-intravenous kwisithuba esingaphantsi kweveki lukwayindlela yonyango, ngakumbi ukuba isifo sibeka ubomi esichengeni.
Usulelo lomngundo olubi lunokuthi lwenzeke kwabo bakhubazekileyo.Aba bantu bayaxhamla kunyango oludityanisiweyo oluquka i-flucytosine, kodwa izehlo zeziphumo ebezingalindelekanga zonyango oludibeneyo, ngakumbi nge-amphotericin B, zinokuba phezulu.

I-5-Fluorocytosine isetyenziselwa ukunyanga izifo zefungal ezibangelwa yi-Cryptococcus kunye neCandida, ezifana ne-fungal sepsis, i-endocarditis, i-meningitis, kunye ne-antifungal agents kwi-lung and urinary tract infections.
Uphawu
Le mveliso inomsebenzi ophezulu we-antifungal ngokuchasene neCandida spp.kunye neCandida spp.kwaye inomsebenzi we-antibacterial ngokuchasene ne-Bacillus spp.kunye neMycobacterium spp.Imveliso i-antibacterial kwi-concentration ephantsi kunye ne-fungicidal ekugxininiseni okuphezulu.Indlela yesenzo kukuthintela ukuhlanganiswa kwe-nucleic acid yefungal.I-fungus kulula ukuvelisa ukuchasana nale mveliso.
Ukulumkela
Idityaniswe ne-amphotericin B, inefuthe le-synergistic, kodwa inokunciphisa ukukhutshelwa kwale mveliso kwizintso kwaye yandise ukuxinana kwegazi, okunokubangela ukusabela okuyityhefu kwizintso kunye nenkqubo yegazi.Ngoko ke, ugxininiso lwegazi oluphezulu kufuneka lubekwe esweni kwaye lugcinwe kwi-50-75μg / ml, olungadluli kwi-100μg / ml;Ukusetyenziswa kwe-bone marrow inhibitors kunokunyusa i-hematological toxicity yale mveliso.
Le mveliso inokubangela ① isicaphucaphu, urhudo, irhashalala, njl.;② ukonakala kwesibindi, ubukhulu becala ukuphakamisa ukusebenza kwesibindi, kodwa kunye ne-hepatomegaly okanye i-hepatic necrosis;③ myelosuppression leukocyte kunye nokuncipha kweplatelet, ngamanye amaxesha kunokubangela i-cytopenia yegazi lonke.Ukunqongophala kwe-granulocytic leukocyte ebulalayo kunye ne-anemia yokubuyisela kuye kwaxelwa;④ Ukubona izinto ezingekhoyo, intloko ebuhlungu kunye nevertigo nazo ziye zaxelwa.Ke ngoko, sebenzisa ngononophelo kwizigulana ezine-hepatic okanye renal impairment, ukuphazamiseka kwegazi, kunye noxinzelelo lomongo.Umfanekiso wegazi weperipheral, umsebenzi wesibindi kunye nezintso kunye nenkqubo yomchamo kufuneka ihlolwe rhoqo xa usebenzisa le mveliso.Inempembelelo ye-teratogenic kuvavanyo lwezilwanyana, kwaye kufuneka isetyenziswe ngononophelo kubasetyhini abakhulelweyo.
Iziphumo ezingalunganga ziquka ukunyuka kwe-transaminases, i-alkaline phosphatase, iimpawu zesisu, i-leukopenia, i-anemia, i-thrombocytopenia, ukukhubazeka kwezintso, intloko ebuhlungu, ukuncipha kwe-acuity yokubona, i-hallucinations, ukungeva kakuhle, i-dyskinesia, ukwehla kwexabiso le-serum ye-potassium, i-calcium kunye ne-phosphorus, kunye ne-allergies (umz. .