I-2-Amino-5-chlorobenzophenone

Isicelo
I-metabolite ye-Diazepam;yaba nefuthe elibuthathaka kakhulu le-anticonvulsant.

Abaphakathi bamayeza.Ukwenziwa kweziyobisi ezifana neLibrium kunye neValium.
Impembelelo yokusingqongileyo
Inobungozi kancinane emanzini, musa ukuvumela ubuninzi obungadityaniswanga okanye ebukhulu ukuba budibane namanzi aphantsi komhlaba, imijelo yamanzi okanye inkqubo yogutyulo, kwaye musa ukukhuphela izixhobo kwindawo engqongileyo ngaphandle kwemvume karhulumente.

Iipropati kunye nozinzo
Izinzile kwiqondo lokushisa kunye noxinzelelo, thintela ukudibanisa nee-oxides

Iindlela zokugcina
Gcina isikhongozeli sivaliwe kwaye usigcine kwindawo epholileyo neyomileyo kwisingxobo esipakishwe nkqi.

Indlela yokudibanisa
(1) Iveliswe ngokusabela kwe-p-chloroaniline kunye ne-benzoyl chloride.Yongeza i-p-chlorobenzene kwimbiza eneglasi yokusabela ekwi-70°C okanye ngaphantsi, faka i-anhydrous zinc chloride, yongeza i-benzoyl chloride dropwise ngokushukumisa, wandule unyuse ubushushu, ubambe ku-195-205°C i-2h, hlamba kahlanu amanzi ashushu kwi-90-95 ° C (uluhlu lwamanzi kunye nesisombululo sokuhlamba sibuyisela i-benzoic acid kunye ne-zinc chloride) malunga ne-100 ° C, yongeza i-sulfuric acid ngokucothayo, ubambe kwi-142 ° C nge-40min.Izinto eziqinileyo ziwela emanzini.Ngaphantsi kokuvuselela, i-pH ilungelelaniswa ne-alkali yolwelo ukuba ingabi ngaphezu kwe-1 kwaye ihluzwe kwi-20-25 °C.Ifiltrate ifunyanwa njengep-chloroaniline.Ikeyiki yokucoca ixutywe kwaye inqunyanyiswe emanzini, ingathathi hlangothi ukuya kwi-pH = 6, ihluziwe yomile, ihlanjwe ngamanzi ukuba ingathathi hlangothi kwaye yomiswe ukufumana imveliso ekrwada.Emva koko wongeza amaxesha angama-6-7 e-ethanol, i-6% ye-carbon activated, i-reflux ye-30min, i-filter kunye ne-crystallize, yomile ukufumana imveliso emihle.(2) i-p-Nitrochlorobenzene kunye ne-cyanobenzyl indibaniselwano yokufumana i-isoxazole, emva koko uvule i-ring, ukunciphisa ukufumana.