Iimveliso
I-2,6-Di-tert-butyl-4-methylpyridine
Ifomula yoLwakhiwo
Imbonakalo: ikristale emhlophe ye-acicular
Ubuninzi: 1,476 g/cm3
Indawo yokunyibilikisa: 31-32 ℃
Indawo yokubila: 148-153℃ (12.6kPa)
Isalathiso se-refractive: N20 /D 1.4763(lit.)
Indawo edanyazayo: 183 °F
Iimeko zokugcina: 2-8°C
I-Acidity coefficient (pKa): 6.88±0.10(Kuqikelelwe)
Idatha yoKhuseleko
Yeyomthwalo jikelele
Ikhowudi yeCustoms: 2942000000
Ixabiso lesaphulelo kwirhafu yempahla yangaphandle (%) : 13%
Isicelo
I-Organic synthetic intermediate, isiseko esithintelwe ngokungqongqo, esingeyo-nucleophilic esahlula phakathi kwe-Brnsted (protonic) kunye ne-Lewis acids.Yenza uguqulelo oluthe ngqo lwesivuno esiphezulu se aldehydes1 kunye ne ketones1,2 ukuya kwi vinyl triflates.
I-2,6-Di-tert-butyl-4-methylpyridine yi-organic compound kunye ne-molecular formula C14H23N, i-intermediate ebalulekileyo kwi-organic synthesis, isetyenziswa kakhulu kwi-pharmaceutical intermediates, i-organic synthesis, i-solvents ye-organic, nayo ingasetyenziswa kwimveliso yedayi, i-pesticide. imveliso kunye neziqholo, njl.
Indlela yokuvelisa
1. Yenza i-2,6 di-tert-butyl-4-methylbenzyl trifluoromethanesulfonate Kwi-100-mL ye-triple flask ene-nitrogen introduction tube, i-funnel yoxinzelelo oluqhubekayo, i-electromagnetic stirring bar kunye ne-ice condenser enetyhubhu eyomileyo, yongeza i-24.2 g (0.2 mol) ye-trimethylethyl phthalide chloride kunye ne-3.7 g (0.05 mol) ye-tert-butanol.Umxube wokusabela utshiswe kwibhafu yeoli ukuya kwi-85 ° C.Emva koko i-15 g (0.1 mol) ye-trifluoromethanesulfonic acid yongezwa ngaphezu kwemizuzu eyi-15.Ukusabela kwaqhutyekwa kwimizuzu eyi-10, kwaye imveliso yokusabela emdaka ekhanyayo yapholiswa kwindawo yokuhlambela yomkhenkce kwaye yagalelwa kwi-100 ml ye-ether ebandayo.Imvula emdaka yahluzwa kwaye yomiswa ukufumana i-9.6 g (54%) yetyuwa ye-buzz ebambezelekayo.(Akukho ukucocwa okufunekayo: kwinyathelo elilandelayo lokulungiselela, phinda uhlaziye kabini ukusuka kwi-chloroform ukuya kwi-carbon tetrachloride 3: 1) ukuya kwiikristale ezingenambala ezifana nenaliti.
2. Ukulungiswa kwe-2,6-Di-tert-butyl-4-methyl-vizine Ngaphantsi kokuvuselela, ukunqunyanyiswa kwe-10 g (0.028 mol) yetyuwa ekrwada ye-vizine kwi-200 mL ye-95% ye-ethanol ebandayo ukuya kuma-60 ° C. idityaniswe kube kanye kwi-100 mL yeammonia egxininisiweyo ebandayo ukuya kuma-60°C kwi-1-litre yegadi-ezantsi yeflaski.Ukusabela kwaqhubeka kwi-60 ° C kwimizuzu engama-30 kunye ne-40 ° C kwiiyure ze-2, ngexesha apho ukumiswa kwachithwa.Emva koko, umxube wokusabela ugalelwe kwi-500 ml ye-2% yesisombululo se-sodium hydroxide efudumala kancinane kwiqondo lobushushu begumbi.Ikhutshwe nge-.4-100 ml ye-pentane, izicatshulwa ezidibeneyo, i-25 ml yesisombululo se-sodium chloride ehluthayo ihlanjwe, i-100 ml ye-pentane rotary evaporator concentration.
