ibhanile12

Iimveliso

L-citrulline

Inkcazelo emfutshane:

I-Citrulline i-α- Amino acid, kunye ne-chemical formula ye-C6H13N3O3, yimveliso eyenziwe kwi-ornithine kunye ne-amino formyl phosphate kumjikelezo we-urea, okanye ukusuka kwi-arginine ekhutshwe yi-nitric oxide synthase (NOS) ukuya kwiNombolo.

Izigulane ezine-rheumatoid arthritis (malunga ne-80%) zihlakulela impendulo yokuzivikela kwiiprotheni ezine-citrulline.Nangona unobangela wale ndlela yokusabela ungaziwa, ukufunyaniswa kwezilwa-buhlungu kunokunceda ekufunyanisweni kolu hlobo lwesifo.


Iinkcukacha zeMveliso

Iithegi zeMveliso

Ifomula yoLwakhiwo

13

Iimbekiselo
1. ikhemikhali > l-glutamic acid.Isiseko sedatha yeMichiza [umhla wokubhekisela: Julayi 5, 2014]
2. biochemistry > common amino acid and protein drug > glutamic acid.Chemical book[umhla wokucaphula: Julayi 5, 2014]
i-glutamic acid cas #: 56-86-0.incwadi yekhemikhali[umhla wokubhekisela: ngo-Epreli 27, 2013]

Ulwazi lweMveliso
Ulwazi lweMveliso
Inombolo yeCas: 372-75-8
Ubunyulu:≥98.5%
Ifomula yomgaqo: C6H13N3O3
Ifomula Wt.Yona: 175.19
Igama leKhemikhali: Urea aminovaleric acid:
Igama le-IUPAC: Urea aminovaleric acid
Indawo yokunyibilika: 222 ℃
Ukunyibilika:Inyibilika emanzini
Imbonakalo :Ikristale emhlophe

Ukuthumela ngenqanawa kunye noGcino
Gcina iTemp:2-8ºC
Ngenqanawa Temp
I-Ambient

Inkcazo
Xa i-citrulline iseyi-amino acid, kuba ayifakwanga kwi-DNA, ayiyi kufakwa kwiiprotheni kwi-protein biosynthesis, kodwa ezinye iiprotheni zisene-citrulline.Ezi citrulline ziveliswa yi-peptide arginine iminase (PAD), eguqula i-arginine kwi-citrulline ngexesha le-melonization.Ngokuqhelekileyo, iiprotheni eziqulethe i-citrulline ziquka iprotheni esisiseko ye-myelin (MBP), i-polykeratin microfilament kunye nezinye i-histones.Ngokomzekelo, i-cellulose kunye ne-vimentin inokuhlanjululwa ngokufa kweeseli kunye nokuvutha kwezicubu.

Iimbekiselo
1.Wan Xueshan, liuwenge, yanzhihong, etc Utshintsho imixholo lycopene, citrulline, VC kunye nezinye izinto ezisebenzayo ngexesha lophuhliso iziqhamo ivatala.VIP, 2011
2.Liu Juan, uLu Xinxin, uMeng Hui Inkqubela phambili yoPhando kwimiphumo ye-pharmacological kunye neendlela zokuvelisa i-citrulline.CNKI;Wanfang, 2011
3.Huang Jing, Lin Hua, Wang Yongxin, Yao di Ukubaluleka kokufunyanwa okudibeneyo kwe-anti cyclic citrullinated peptide antibody, i-anti keratin antibody, i-anti perinuclear factor antibody kunye ne-rheumatoid factor ekuxilongweni kwe-rheumatoid arthritis endala.CNKI, 2010


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