Iimveliso
Doxifluridine
Ifomula yoLwakhiwo
Ngokwasemzimbeni
Imbonakalo:mhlophe Ziqinile
Ubuninzi: 1.3751 (uqikelelo)
Indawo yokunyibilika:188-192 °c(lit.)
Ukujikeleziswa okuthe ngqo :d25 +18.4° (c = 0.419 Emanzini)
Refractivity:20 °(c=1, H2o)
Imeko yoGcino: Imosphere engasebenziyo, ubushushu begumbi
I-Acidity Factor(pka):7.4(at 25℃)
Idatha yoKhuseleko
Udidi lwengozi:Ayiyompahla eyingozi
Inombolo yothutho lwempahla eyingozi:
Udidi lokuPakisha:
Isicelo
1. Njengemveliso ye-5-Flurouridine.I-nucleoside ye-pyrimidine ene-fluorinated kunye nomsebenzi we-cytostatic.Eklinikhi esetyenziselwa umhlaza wesisu, umhlaza wesisu, umhlaza wamabele, izinga loxolelo linokufikelela ngaphezulu kwama-30%.
2. Njengombindi weFluorouracil antitumor drug
Intshayelelo kusetyenziso
1. I-Fluorouracil-based antitumour agents zizandulela ze-fluorouracil.I-enzyme i-thymidine phosphorylase, ekhoyo kwizicubu ze-tumor, isebenza kuyo ukuyiguqula ibe yi-fluorouracil kwi-tumor, ngaloo ndlela yenza i-anti-tumour effect.Inomlinganiselo oqinileyo wokuchasana nethumba kunye netyhefu ephantsi.Isetyenziswa ngokweklinikhi kumhlaza wesisu, umhlaza wesisu kunye nomhlaza webele, kunye nezinga lokuxolelwa ukuya kuthi ga kwi-30% okanye ngaphezulu.
2. Pharmaceutical intermediate.
3. I-agent ye-antitumour, i-precursor drug ye-fluorouracil (5-FU), eguqulwa ibe yi-fluorouracil yamahhala ngesenzo se-pyrimidine nucleoside phosphorylase kwizicubu ze-tumor, ngaloo ndlela inqanda i-biosynthesis ye-DNA kunye ne-RNA kwiiseli ze-tumor kwaye ibonise impembelelo ye-antitumour.Ekubeni umsebenzi wale enzyme uphezulu kwizicubu ze-tumor kunezicubu eziqhelekileyo, ukuguqulwa kwe-5-FU ibe yi-5-FU kwizicubu ze-tumor ngokukhawuleza kwaye zikhethela amathumba.Isetyenziswa kunyango lwebele, isisu kunye nomhlaza we-rectal kwaye inetyhefu ephantsi.
